Ammonium salts as convenient ammonia surrogates in the willgerodt reaction

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Abstract

A novel solventless modification of the Willgerodt reaction is proposed. It employs elemental sulfur and ammonium salts as safe and convenient surrogates of ammonia on a solid carrier. The reaction involving combination of ammonium carbonate and aluminum oxide results in the amides of aryl acetic acids with yields from 48 to 85%.

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About the authors

E. A. Kvetkin

Samara State Medical University

Author for correspondence.
Email: eakvetkin@gmail.com
ORCID iD: 0009-0009-1014-0297
Russian Federation, Chapayevskaya St., 89, Samara, 443099

A. V. Sokolov

Samara State Medical University

Email: eakvetkin@gmail.com
ORCID iD: 0000-0003-4965-3136
Russian Federation, Chapayevskaya St., 89, Samara, 443099

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Supplementary files

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2. Scheme

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3. Figure: Yields of the Wilgerodt reaction products

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4. Figure

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