New chemical transformation of substituted dinitroacetonitrile in the reaction with isoquinoline in presence of dimethylbut-2-indioate

A. G. Tyrkov; Тырков А. Г.; Е. A. Yurtaeva; Юртаева Е. А.

doi:10.31857/S0514749225020115

New chemical transformation of substituted dinitroacetonitrile in the reaction with isoquinoline in presence of dimethylbut-2-indioate

Authors: Tyrkov A.G.¹, Yurtaeva Е.A.²
Affiliations:
1. Astrakhan Tatishchev State University
2. Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University
Issue: Vol 61, No 2 (2025)
Pages: 203-207
Section: Articles
URL: https://www.clinpractice.ru/0514-7492/article/view/684335
DOI: https://doi.org/10.31857/S0514749225020115
EDN: https://elibrary.ru/DHGICS
ID: 684335

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Abstract

The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethylbut-2-indioate results in the formation of 1,3-dipolar cycloaddition products – a mixture of diastereomeric dimethyl-2-dinitromethyl-1,1bH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.

Keywords

substituted dinitroacetonitrile, isoquinoline, dimethylbut-2-indioate, three-component heterocyclization, 1, 3-dipolar cycloaddition, dimethyl-2-dinitromethyl-1, 1bH-pyrimido[2, 1-a]isoquinoline-3, 4-dicarboxylates

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About the authors

A. G. Tyrkov

Astrakhan Tatishchev State University

Author for correspondence.
Email: tyrkov@rambler.ru
Russian Federation, pl. Shaumyana, 1, Astrakhan, 414000

Е. A. Yurtaeva

Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University

Email: tyrkov@rambler.ru
Russian Federation, prosp. Kalinina, 11, Pyatigorsk, 357532

References

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